Map1a Gene Summary [Rat]
Enables actin binding activity; collagen binding activity; and microtubule binding activity. A structural constituent of presynapse. Involved in negative regulation of microtubule depolymerization. Located in several cellular components, including axon; dendrite; and neuronal cell body. Part of microtubule associated complex. Is active in glutamatergic synapse; postsynaptic density; and presynaptic active zone. Biomarker of hypothyroidism. Orthologous to human MAP1A (microtubule associated protein 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map1a |
| Official Name | microtubule-associated protein 1A [Source:RGD Symbol;Acc:3042] |
| Ensembl ID | ENSRNOG00000014230 |
| Bio databases IDs | |
| Aliases | microtubule-associated protein 1A |
| Synonyms | 6330416M19RIK, MAP1L, microtubule-associated protein 1 A, moth1, Mtap-1, MTAP1A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Map1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding domain
- Domain of unknown function (DUF4515)
- RNase Y N-terminal region
- constant light chain domain
- guanylate kinase binding domain
- Tropomyosin like
- PspA/IM30 family
- Hyaluronan mediated motility receptor N-terminal
- protein binding
- ionotropic glutamate receptor binding
- microtubule associated protein light chain domain
- cytoskeletal adaptor
- microtubule binding
- tubulin binding
- Trichohyalin-plectin-homology domain
- actin binding
- self similar domain
- Growth-arrest specific micro-tubule binding
- collagen binding
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- Klinefelter syndrome
- prostatic neoplasm
- Turner syndrome
- neurodevelopmental disorder
- tremor
- ataxia
role in cell
- regulation
- maintenance
- morphology
- abnormal morphology
- assembly
- homeostasis
- loss
- quantity
- trafficking in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule fractions
- glutaminergic synapse
- axon component
- somatodendritic region
- cellular membrane
- filamentous network
- microtubules
- cytosol
- neurites
- axon initial segments
- synapse
- photoreceptor outer segments
- perikaryon
- axons
- dendrites
- postsynaptic density
- dendritic shafts
- dendritic branches
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Map1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron homeostasis
- voluntary musculoskeletal movement
- positive regulation of protein localization at cell surface
- axonogenesis
- regulation of synaptic plasticity
- microtubule cytoskeleton organization
- associative learning
- memory
- regulation of microtubule depolymerization
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- dendrite development
Cellular Component
Where in the cell the gene product is active
- dendritic branch
- neuronal cell body
- synapse
- neuron projection
- microtubule associated complex
- microtubule
- dendrite
- initial segment
- cytoplasm
- dendritic shaft
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- cytoskeletal adaptor activity
- protein binding
- actin binding
- tau protein binding
- structural molecule activity
- microtubule binding