MAP1A Gene Summary [Human]
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain. Expression of this gene is almost exclusively in the brain. Studies of the rat microtubule-associated protein 1A gene suggested a role in early events of spinal cord development. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP1A |
| Official Name | microtubule associated protein 1A [Source:HGNC Symbol;Acc:HGNC:6835] |
| Ensembl ID | ENSG00000166963 |
| Bio databases IDs | |
| Aliases | microtubule associated protein 1A |
| Synonyms | 6330416M19RIK, MAP1L, microtubule-associated protein 1 A, moth1, Mtap-1, MTAP1A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding domain
- Domain of unknown function (DUF4515)
- RNase Y N-terminal region
- constant light chain domain
- guanylate kinase binding domain
- Tropomyosin like
- PspA/IM30 family
- Hyaluronan mediated motility receptor N-terminal
- protein binding
- ionotropic glutamate receptor binding
- microtubule associated protein light chain domain
- cytoskeletal adaptor
- microtubule binding
- tubulin binding
- Trichohyalin-plectin-homology domain
- actin binding
- self similar domain
- Growth-arrest specific micro-tubule binding
- collagen binding
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- Klinefelter syndrome
- prostatic neoplasm
- Turner syndrome
- neurodevelopmental disorder
- tremor
- ataxia
role in cell
- regulation
- maintenance
- morphology
- abnormal morphology
- assembly
- homeostasis
- loss
- quantity
- trafficking in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule fractions
- glutaminergic synapse
- axon component
- somatodendritic region
- cellular membrane
- filamentous network
- microtubules
- cytosol
- neurites
- axon initial segments
- synapse
- photoreceptor outer segments
- perikaryon
- axons
- dendrites
- postsynaptic density
- dendritic shafts
- dendritic branches
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron homeostasis
- voluntary musculoskeletal movement
- positive regulation of protein localization at cell surface
- axonogenesis
- regulation of synaptic plasticity
- microtubule cytoskeleton organization
- associative learning
- memory
- regulation of microtubule depolymerization
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- dendrite development
Cellular Component
Where in the cell the gene product is active
- dendritic branch
- neuronal cell body
- synapse
- neuron projection
- microtubule associated complex
- microtubule
- dendrite
- initial segment
- cytoplasm
- dendritic shaft
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- cytoskeletal adaptor activity
- protein binding
- actin binding
- tau protein binding
- structural molecule activity
- microtubule binding