Map1a Gene Summary [Mouse]
Enables cytoskeletal anchor activity; cytoskeletal protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including axo-dendritic protein transport; learning or memory; and regulation of protein localization. Acts upstream of or within photoreceptor cell maintenance and sensory perception of sound. Located in several cellular components, including axon initial segment; dendritic microtubule; and postsynaptic density. Is expressed in cerebral cortex marginal zone; cortical plate; cortical subplate; and spinal cord. Orthologous to human MAP1A (microtubule associated protein 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map1a |
| Official Name | microtubule-associated protein 1 A [Source:MGI Symbol;Acc:MGI:1306776] |
| Ensembl ID | ENSMUSG00000027254 |
| Bio databases IDs | |
| Aliases | microtubule-associated protein 1 A |
| Synonyms | 6330416M19RIK, MAP1L, microtubule-associated protein 1 A, moth1, Mtap-1, MTAP1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding domain
- Domain of unknown function (DUF4515)
- RNase Y N-terminal region
- constant light chain domain
- guanylate kinase binding domain
- Tropomyosin like
- PspA/IM30 family
- Hyaluronan mediated motility receptor N-terminal
- protein binding
- ionotropic glutamate receptor binding
- microtubule associated protein light chain domain
- cytoskeletal adaptor
- microtubule binding
- tubulin binding
- Trichohyalin-plectin-homology domain
- actin binding
- self similar domain
- Growth-arrest specific micro-tubule binding
- collagen binding
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- Klinefelter syndrome
- prostatic neoplasm
- Turner syndrome
- neurodevelopmental disorder
- tremor
- ataxia
role in cell
- regulation
- maintenance
- morphology
- abnormal morphology
- assembly
- homeostasis
- loss
- quantity
- trafficking in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule fractions
- glutaminergic synapse
- axon component
- somatodendritic region
- cellular membrane
- filamentous network
- microtubules
- cytosol
- neurites
- axon initial segments
- synapse
- photoreceptor outer segments
- perikaryon
- axons
- dendrites
- postsynaptic density
- dendritic shafts
- dendritic branches
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron homeostasis
- voluntary musculoskeletal movement
- positive regulation of protein localization at cell surface
- axonogenesis
- regulation of synaptic plasticity
- microtubule cytoskeleton organization
- associative learning
- memory
- regulation of microtubule depolymerization
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- dendrite development
Cellular Component
Where in the cell the gene product is active
- dendritic branch
- neuronal cell body
- synapse
- neuron projection
- microtubule associated complex
- microtubule
- dendrite
- initial segment
- cytoplasm
- dendritic shaft
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- cytoskeletal adaptor activity
- protein binding
- actin binding
- tau protein binding
- structural molecule activity
- microtubule binding