Gtf2e2 Gene Summary [Rat]
Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to contribute to TFIIH-class transcription factor complex binding activity. Predicted to be involved in transcription initiation at RNA polymerase II promoter. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription factor TFIID complex and transcription factor TFIIE complex. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gtf2e2 |
| Official Name | general transcription factor IIE subunit 2 [Source:RGD Symbol;Acc:1310134] |
| Ensembl ID | ENSRNOG00000014422 |
| Bio databases IDs | |
| Aliases | general transcription factor IIE subunit 2 |
| Synonyms | C330006J08Rik, FE, general transcription factor II E, polypeptide 2 (beta subunit), general transcription factor II E, polypeptide 2 (β subunit), general transcription factor IIE subunit 2, TF2E2, TFIIE-B, TFIIE p34, TTD6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gtf2e2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription factor IIE beta winged-helix domain
- basic helix-loop domain
- transcription regulator
- protein binding
- general RNA polymerase II transcription factor
- helix-loop-helix domain
- TFA2 Winged helix domain 2
- basic domain
Pathways
Biological processes and signaling networks where the Gtf2e2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- open-angle glaucoma
- COVID-19
- androgenic alopecia
- nonphotosensitive trichothiodystrophy type 6
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gtf2e2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor TFIID complex
- cytosol
- transcription factor TFIIE complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- TFIIH-class transcription factor binding
- general RNA polymerase II transcription factor activity