Gmps Gene Summary [Rat]
Enables GMP synthase activity and enzyme binding activity. Involved in GMP salvage; response to L-cysteine; and response to xenobiotic stimulus. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gmps |
| Official Name | guanine monophosphate synthase [Source:RGD Symbol;Acc:1310063] |
| Ensembl ID | ENSRNOG00000051151 |
| Bio databases IDs | |
| Aliases | guanine monophosphate synthase |
| Synonyms | GATD7, Gm9479, guanine monophosphate synthase, guanine monophosphate synthetase, Guanine Monphosphate Synthetase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gmps often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptidase C26
- GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit
- Glutamine amidotransferase class-I
- GMP synthase (glutamine-hydrolysing)
- GMP synthase
- enzyme binding
- enzyme
- GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit
- Type 1 glutamine amidotransferase (GATase1)-like domain
- Adenine nucleotide alpha hydrolase (AANH) superfamily
- GMP synthase C terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gmps gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamine metabolic process
- purine base biosynthetic process
- GMP biosynthetic process
- purine ribonucleoside monophosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- GMP synthase activity
- GMP synthase (glutamine-hydrolyzing) activity