Ppp1r10 Gene Summary [Rat]
Enables protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitotic DNA damage checkpoint; and positive regulation of telomere maintenance. Located in chromatin. Orthologous to human PPP1R10 (protein phosphatase 1 regulatory subunit 10). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ppp1r10 |
| Official Name | protein phosphatase 1, regulatory subunit 10 [Source:RGD Symbol;Acc:620079] |
| Ensembl ID | ENSRNOG00000059268 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory subunit 10 |
| Synonyms | 2610025H06Rik, CAT53, D17ERTD808E, FB19, p99, PNUTS, PP1R10, protein phosphatase 1 regulatory subunit 10, protein phosphatase 1, regulatory subunit 10, R111 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp1r10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger
- protein phosphatase inhibitor activity
- protein phosphatase 1 binding
- TFIIS helical bundle-like domain
- CCCH-type zinc finger
- protein binding activity, bridging
- protein phosphatase regulator
- Zinc finger C-x8-C-x5-C-x3-H type (and similar)
- protein binding
Pathways
Biological processes and signaling networks where the Ppp1r10 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- ERK/MAPK Signaling
- HIPPO signaling
- Insulin Receptor Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Protein Kinase A Signaling
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- postmenopausal osteoporosis
- nonalcoholic fatty liver disease
- esophageal squamous cell carcinoma
- insomnia
- psoriasis
- pemphigus vulgaris
- gastric carcinoma
- gastric epithelial cancer
- myocardial dysfunction
- esophageal adenocarcinoma
role in cell
- apoptosis
- proliferation
- cell death
- cell cycle progression
- accumulation
- accumulation in
- DNA damage response
- decondensation in
- shortening in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
- interchromatin granule clusters
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp1r10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein import into nucleus
- negative regulation of cardiac muscle cell apoptotic process
- positive regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- nuclear body
- PTW/PP1 phosphatase complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- DNA binding
- protein binding
- RNA binding
- metal ion binding
- protein phosphatase 1 binding