Entpd1 Gene Summary [Rat]
Enables ADP phosphatase activity; ATP hydrolysis activity; and identical protein binding activity. Involved in several processes, including cellular response to aluminum ion; cellular response to cytokine stimulus; and negative regulation of dopamine secretion. Located in several cellular components, including basolateral plasma membrane; synaptic membrane; and synaptic vesicle. Biomarker of demyelinating disease; hypothyroidism; intrahepatic cholestasis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Entpd1 |
| Official Name | ectonucleoside triphosphate diphosphohydrolase 1 [Source:RGD Symbol;Acc:69265] |
| Ensembl ID | ENSRNOG00000014574 |
| Bio databases IDs | |
| Aliases | ectonucleoside triphosphate diphosphohydrolase 1 |
| Synonyms | 2610206B08Rik, APYRASE, ATPDase, ATP-DPH, CD39, E130009M23Rik, Ecto-apyrase, ectonucleoside triphosphate diphosphohydrolase 1, Ectonucleotidase, LOC103689954, NTPDase-1, SPG64 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Entpd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-triphosphatase
- nucleoside-diphosphatase
- apyrase
- cytoplasmic domain
- N-linked glycosylation site
- transmembrane domain
- enzyme
- protein binding
- identical protein binding
- ATPase
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- edema
- cancer
- neoplasia
- fibrosis
- metastasis
- liver cancer
- autosomal recessive spastic paraplegia type 64
- cutaneous melanoma cancer
- skin cancer
role in cell
- differentiation
- degradation in
- expression in
- formation
- formation in
- aggregation
- proliferation
- production in
- depletion in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- apical membrane
- caveolae
- synaptic membrane
- basolateral membrane
- synaptic vesicles
- membrane rafts
- microvilli
- perikaryon
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Entpd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleoside diphosphate catabolic process
- cell adhesion
- blood coagulation
- platelet aggregation
Cellular Component
Where in the cell the gene product is active
- caveola
- extracellular vesicular exosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- apyrase activity
- CTPase activity
- adenosine-diphosphatase activity
- uridine-diphosphatase activity
- GTPase activity
- guanosine-diphosphatase activity
- nucleoside-diphosphatase activity
- nucleoside-triphosphatase activity