Aqp8 Gene Summary [Rat]
Enables ammonium channel activity; methylammonium channel activity; and water channel activity. Involved in several processes, including ammonium import across plasma membrane; canalicular bile acid transport; and hydrogen peroxide transmembrane transport. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and intracellular canaliculus. Biomarker of brain ischemia. Orthologous to human AQP8 (aquaporin 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aqp8 |
| Official Name | aquaporin 8 [Source:RGD Symbol;Acc:2146] |
| Ensembl ID | ENSRNOG00000014652 |
| Bio databases IDs | |
| Aliases | aquaporin 8 |
| Synonyms | aquaporin 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aqp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MIP
- protein binding
- water channel
- ammonium transporter
- methylammonium channel
- transporter
- urea channel
Pathways
Biological processes and signaling networks where the Aqp8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- colorectal adenoma
- colorectal adenoma formation
- metastatic prostate cancer
- non-insulin-dependent diabetes mellitus
- ulcerative colitis
- primary prostate cancer
regulates
- reactive oxygen species
- PTEN
- triacylglycerol
- cholesterol
- AKT
- urea
- methylamine
- bile acid
- water
- hydrogen peroxide
role in cell
- expression in
- apoptosis
- production in
- differentiation
- migration
- proliferation
- invasion
- swelling
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- intracellular space
- apical compartment
- intracellular membranes
- cellular membrane
- inner membrane
- vesicles
- Mitochondria
- cytosol
- apical membrane
- basolateral membrane
- mitochondrial membrane
- mitochondrial inner membrane
- smooth endoplasmatic reticulum
- mitoplasts
- microsomal membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aqp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hydrogen peroxide transmembrane transport
- urea transport
- water transport
- transepithelial water transport
- ammonium transmembrane transport
- regulation of cholesterol biosynthetic process
- B cell differentiation
- urea transmembrane transport
- cellular response to cAMP
- methylammonium transmembrane transport
- methylammonium transport
Cellular Component
Where in the cell the gene product is active
- intracellular canaliculus
- smooth endoplasmic reticulum membrane
- mitochondrial membrane
- brush border membrane
- apical part of cell
- smooth endoplasmic reticulum
- mitochondrion
- basolateral plasma membrane
- apical plasma membrane
- mitochondrial inner membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ammonium transmembrane transporter activity
- protein binding
- urea channel activity
- methylammonium channel activity
- water channel activity