Exog Gene Summary [Rat]
Predicted to enable 5'-3' exonuclease activity; RNA endonuclease activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be located in mitochondrion. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Exog |
| Official Name | exo/endonuclease G [Source:RGD Symbol;Acc:1304628] |
| Ensembl ID | ENSRNOG00000014801 |
| Bio databases IDs | |
| Aliases | exo/endonuclease G |
| Synonyms | ENDOGL1, ENDOGL2, ENGL, ENGL-a, ENGL-B, exo/endonuclease G |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Exog often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endonuclease
- Endo/exonuclease (EXOG) C-terminal domain
- 5'-3' exonuclease
- DNA/RNA non-specific endonuclease
- NUC
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Exog gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic DNA fragmentation
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- macromolecular complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- 5'-3' exonuclease activity
- nucleic acid binding
- metal ion binding
- endonuclease activity
- single-stranded DNA specific endodeoxyribonuclease activity
- endoribonuclease activity