Eif2b2 Gene Summary [Rat]
Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; positive regulation of axon extension; and response to glucose. Located in axon. Part of eukaryotic translation initiation factor 2B complex. Is active in endoplasmic reticulum; glycinergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 2. Orthologous to human EIF2B2 (eukaryotic translation initiation factor 2B subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif2b2 |
| Official Name | eukaryotic translation initiation factor 2B subunit beta [Source:RGD Symbol;Acc:620820] |
| Ensembl ID | ENSRNOG00000006467 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 2B subunit beta |
| Synonyms | AA409345, C85417, EIF2B, EIF-2Bbeta, eukaryotic translation initiation factor 2B, subunit 2 beta, eukaryotic translation initiation factor 2B, subunit 2 β, eukaryotic translation initiation factor 2B subunit beta, eukaryotic translation initiation factor 2B subunit β, VWM2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eif2b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- guanyl-nucleotide exchange factor
- ATP binding
- Initiation factor 2 subunit family
- translation initiation factor
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the Eif2b2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- leukoencephalopathy with vanishing white matter
- leukoencephalopathy with vanishing white matter type 2
- adult-onset leukoencephalopathy with vanishing white matter type 2
- hereditary disorder
- androgenic alopecia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- leukoencephalopathy with vanishing white matter type 1
- premature ovarian failure
- osteogenesis imperfecta
role in cell
- growth
- development
- outgrowth
- outgrowth in
- extension
- synthesis in
- myelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic region
- Endoplasmic Reticulum
- cytosol
- synapse
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eif2b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte development
- response to heat
- response to glucose stimulus
- central nervous system development
- cytoplasmic translational initiation
- myelination
- translational initiation
- regulation of translational initiation
- response to peptide hormone stimulus
- T cell receptor signaling pathway
- ovarian follicle development
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- eukaryotic translation initiation factor 2B complex
Molecular Function
What the gene product does at the molecular level
- GTP binding
- translation initiation factor activity
- ATP binding
- protein binding
- guanyl-nucleotide exchange factor activity