EXOG Gene Summary [Human]
This gene encodes an endo/exonuclease with 5'-3' exonuclease activity. The encoded enzyme catalyzes the hydrolysis of ester linkages at the 5' end of a nucleic acid chain. This enzyme is localized to the mitochondria and may play a role in programmed cell death. Alternatively spliced transcript variants have been described. A pseudogene exists on chromosome 18. [provided by RefSeq, Feb 2009]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | EXOG |
| Official Name | exo/endonuclease G [Source:HGNC Symbol;Acc:HGNC:3347] |
| Ensembl ID | ENSG00000157036 |
| Bio databases IDs | |
| Aliases | exo/endonuclease G |
| Synonyms | ENDOGL1, ENDOGL2, ENGL, ENGL-a, ENGL-B, exo/endonuclease G |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EXOG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endonuclease
- Endo/exonuclease (EXOG) C-terminal domain
- 5'-3' exonuclease
- DNA/RNA non-specific endonuclease
- NUC
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EXOG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic DNA fragmentation
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- macromolecular complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- 5'-3' exonuclease activity
- nucleic acid binding
- metal ion binding
- endonuclease activity
- single-stranded DNA specific endodeoxyribonuclease activity
- endoribonuclease activity