Anp32a Gene Summary [Rat]
Enables integrin binding activity. Involved in negative regulation of plasma membrane bounded cell projection assembly and negative regulation of protein modification process. Located in chromatin. Orthologous to several human genes including ANP32A (acidic nuclear phosphoprotein 32 family member A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Anp32a |
| Official Name | acidic nuclear phosphoprotein 32 family member A [Source:RGD Symbol;Acc:11508551] |
| Ensembl ID | ENSRNOG00000014846 |
| Bio databases IDs | |
| Aliases | acidic nuclear phosphoprotein 32 family member A |
| Synonyms | acidic nuclear phosphoprotein 32 family member A, Anp32, C15orf1, HPPCn, I1PP2A, LANP, LNAP, MAPM, NEWGENE 2116, PHAP1, PHAPI, PP32, PUTATIVEHLA CLASS II ASSOCIATED protein I, PUTATIVE HLA CLASS II ASSOIATED protein I, W91701 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Anp32a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inhibitor of histone acetyltransferase domain
- leucine rich domain
- leucine-rich repeat
- aspartate-glutamate rich domain
- cell adhesion molecule binding
- integrin binding
- Leucine rich repeat
- protein binding
- Leucine Rich repeats (2 copies)
- acidic domain
Pathways
Biological processes and signaling networks where the Anp32a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- metastasis
- Alzheimer disease
- psoriasis
- neonatal late-onset sepsis
- aortic valve calcification
- androgenic alopecia
role in cell
- apoptosis
- binding
- phosphorylation in
- expression in
- proliferation
- growth
- formation
- activation in
- migration
- localization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- perinuclear region
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
- nuclear matrix
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Anp32a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- regulation of apoptotic process
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- histone binding