Aldh8a1 Gene Summary [Rat]
Predicted to enable retinal dehydrogenase activity. Predicted to be involved in retinal metabolic process and retinoic acid metabolic process. Predicted to act upstream of or within 9-cis-retinoic acid biosynthetic process. Orthologous to human ALDH8A1 (aldehyde dehydrogenase 8 family member A1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh8a1 |
| Official Name | aldehyde dehydrogenase 8 family, member A1 [Source:RGD Symbol;Acc:1590218] |
| Ensembl ID | ENSRNOG00000014907 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 8 family, member A1 |
| Synonyms | aldehyde dehydrogenase 8 family member A1, aldehyde dehydrogenase 8 family, member A1, ALDH12, DJ352A20.2, LOC683474, Raldh4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldh8a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
- betaine-aldehyde dehydrogenase
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 1
- retinal dehydrogenase
- enzyme
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative
- 2-hydroxymuconic semialdehyde dehydrogenase
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the Aldh8a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldh8a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 9-cis-retinoic acid biosynthetic process
- retinoic acid metabolic process
- retinal metabolic process
- L-kynurenine catabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- aminomuconate-semialdehyde dehydrogenase activity
- retinal dehydrogenase activity