Aldh6a1 Gene Summary [Rat]
Enables methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity and thiolester hydrolase activity. Involved in beta-alanine catabolic process; thymine catabolic process; and valine catabolic process. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human ALDH6A1 (aldehyde dehydrogenase 6 family member A1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh6a1 |
| Official Name | aldehyde dehydrogenase 6 family, member A1 [Source:RGD Symbol;Acc:621556] |
| Ensembl ID | ENSRNOG00000011419 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 6 family, member A1 |
| Synonyms | 1110038I05Rik, AI427784, aldehyde dehydrogenase 6 family member A1, aldehyde dehydrogenase 6 family, member A1, aldehyde dehydrogenase family 6, subfamily A1, Aldh6a, LOC100506517, Methylmalonate-semialdehyde dehydrogenase, MMSADHA, MMSDH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldh6a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- thiolester hydrolase
- Aldehyde dehydrogenase family
- betaine-aldehyde dehydrogenase
- methylmalonate-semialdehyde dehydrogenase (acylating)
- aldehyde dehydrogenase, Rv0768 family
- enzyme
- malonate-semialdehyde dehydrogenase (acetylating)
- methylmalonic acid semialdehyde dehydrogenase
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
Pathways
Biological processes and signaling networks where the Aldh6a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- Huntington disease
- hepatocellular carcinoma
- methylmalonate semialdehyde dehydrogenase deficiency
- survival
- hepatitis B virus-related hepatocellular carcinoma
- hereditary disorder
regulates
- thymine
- beta-alanine
- valine
- branched chain amino acids
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Mitochondria
- cytosol
- mitochondrial matrix
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldh6a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- brown fat cell differentiation
- thymine metabolic process
- branched chain family amino acid catabolic process
- valine catabolic process
- valine metabolic process
- thymine catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- methylmalonate-semialdehyde dehydrogenase (acylating) activity
- malonate-semialdehyde dehydrogenase (acetylating) activity