Dmpk Gene Summary [Rat]
Predicted to enable ATP binding activity; myosin phosphatase regulator activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including muscle cell apoptotic process; regulation of skeletal muscle contraction by calcium ion signaling; and regulation of synapse structural plasticity. Predicted to act upstream of or within regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction and regulation of sodium ion transport. Predicted to be located in several cellular components, including bounding membrane of organelle; cytosol; and nuclear membrane. Human ortholog(s) of this gene implicated in myotonic dystrophy type 1. Orthologous to human DMPK (DM1 protein kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dmpk |
| Official Name | DM1 protein kinase [Source:RGD Symbol;Acc:1309825] |
| Ensembl ID | ENSRNOG00000015085 |
| Bio databases IDs | |
| Aliases | DM1 protein kinase |
| Synonyms | DM, DM1, DM15, DM1PK, DM1 protein kinase, DMK, Dmpk predicted, dystrophia myotonica-protein kinase, MDK, MDPK, MT-PK, MYOTONIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dmpk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- myosin phosphatase regulator
- Protein tyrosine and serine/threonine kinase
- ATP binding
- coiled-coil domain
- DMPK coiled coil domain like
- protein binding
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- alcohol group acceptor phosphotransferase
- Kinase-like
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myotonic dystrophy type 1
- progressive muscle weakness
- amyotrophic lateral sclerosis
- heart block
- myopathy
- myotonic dystrophy
- atrial ventricular block
role in cell
- apoptosis
- differentiation
- size
- abnormal morphology
- lack
- premature senescence
- homeostasis in
- diameter
- function
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- outer membranes
- Plasma Membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dmpk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear envelope organization
- regulation of sodium ion transport
- regulation of heart contraction
- regulation of myotube differentiation
- muscle cell apoptotic process
- protein phosphorylation
- peptidyl-serine phosphorylation
- regulation of skeletal muscle contraction by calcium ion signaling
- regulation of synapse structural plasticity
- regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear membrane
- cytosol
- nuclear outer membrane
- mitochondrial outer membrane
- plasma membrane
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- myosin phosphatase regulator activity
- protein serine/threonine kinase activity