Mcoln2 Gene Summary [Rat]
Predicted to enable NAADP-sensitive calcium-release channel activity; identical protein binding activity; and iron ion transmembrane transporter activity. Predicted to be involved in calcium-mediated signaling and iron ion transmembrane transport. Predicted to act upstream of or within myeloid leukocyte migration and positive regulation of chemokine production. Predicted to be located in recycling endosome. Predicted to be active in membrane. Orthologous to human MCOLN2 (mucolipin TRP cation channel 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcoln2 |
| Official Name | mucolipin 2 [Source:RGD Symbol;Acc:1308884] |
| Ensembl ID | ENSRNOG00000015089 |
| Bio databases IDs | |
| Aliases | mucolipin 2 |
| Synonyms | 3300002C04Rik, mucolipin 2, mucolipin TRP cation channel 2, TRP-ML2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mcoln2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ion transport protein
- ELD_TRPML
- calcium channel
- iron ion transporter
- identical protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multicentric carpotarsal osteolysis syndrome
role in cell
- cell viability
- recruitment
- production in
- cell death
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- lysosome
- lysosome membrane
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mcoln2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of monocyte chemotactic protein-1 production
- positive regulation of chemokine (C-C motif) ligand 5 production
- innate immune response
- protein transport
- calcium ion transmembrane transport
- positive regulation of chemokine (C-X-C motif) ligand 2 production
- adaptive immune response
- positive regulation of macrophage inflammatory protein 1 alpha production
- calcium-mediated signaling
- iron ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- membrane
- recycling endosome membrane
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- NAADP-sensitive calcium-release channel activity
- iron ion transmembrane transporter activity
- calcium channel activity