Utrn Gene Summary [Rat]
Enables actin filament binding activity. Involved in neuromuscular junction development and response to denervation involved in regulation of muscle adaptation. Located in cortical actin cytoskeleton; growth cone; and neuromuscular junction. Orthologous to human UTRN (utrophin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Utrn |
| Official Name | utrophin [Source:RGD Symbol;Acc:3947] |
| Ensembl ID | ENSRNOG00000011058 |
| Bio databases IDs | |
| Aliases | utrophin |
| Synonyms | DMDL, DRP, DRP-1, Utrophin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Utrn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- EF-Hand
- ZZ
- exonuclease SbcC
- protein kinase binding
- Calponin homology domain
- coiled-coil domain
- vinculin binding
- protein binding
- WW domain
- actin filament binding
- chromosome segregation protein SMC, common bacterial type
- Spectrin repeats
- Domain with 2 conserved Trp (W) residues
- actin binding
- EF hand
- integrin binding
- WW
- EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
- calponin homology (CH) domain superfamily
- Spectrin repeat
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Utrn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- idiopathic scoliosis
- breast cancer
- testicular cancer
- restless legs syndrome
- fibrosis
- colon cancer
- liver cancer
- prostate cancer
- rectum cancer
role in cell
- cellular infiltration by
- number
- accumulation
- growth
- quantity
- morphology
- myogenic potential
- abnormal morphology
- lysis
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- cortical actin cytoskeleton
- intracellular compartment
- Cajal band
- cytoskeleton
- Cytoplasm
- cilia
- cell surface
- intracellular space
- basal compartment
- cellular membrane
- basal bodies
- contractile rings
- cytosol
- basal cell surfaces
- postsynaptic membrane
- basolateral membrane
- sinusoidal membrane
- nucleoplasm
- nuclear scaffolds
- acrosome
- neuromuscular junctions
- growth cone
- synapse
- intercalated disks
- sarcolemma
- myotendinous junctions
- secretory granules
- filopodia
- basement membrane
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Utrn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- positive regulation of cell-matrix adhesion
- muscle contraction
- regulation of sodium ion transmembrane transporter activity
Cellular Component
Where in the cell the gene product is active
- contractile ring
- plasma membrane
- nucleoplasm
- filopodium membrane
- cytoskeleton
- extracellular vesicular exosome
- cytoplasm
- postsynaptic membrane
- sarcolemma
- membrane
- dystrophin-associated glycoprotein complex
- filopodium
- macromolecular complex
- neuromuscular junction
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- protein binding
- actin binding
- vinculin binding
- integrin binding