Sparcl1 Gene Summary [Rat]
Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Involved in regulation of synapse organization. Is active in extracellular matrix of synaptic cleft and glutamatergic synapse. Orthologous to human SPARCL1 (SPARC like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sparcl1 |
| Official Name | SPARC like 1 [Source:RGD Symbol;Acc:2531] |
| Ensembl ID | ENSRNOG00000015093 |
| Bio databases IDs | |
| Aliases | SPARC like 1 |
| Synonyms | Ecm2, ECM protein 2, hevin, MAST 9, PIG33, SC1, SPARC-like 1, SPRL1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sparcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EFh_SPARC_EC
- Secreted protein acidic and rich in cysteine Ca binding region
- protein binding
- KAZAL_FS
- Follistatin/Osteonectin-like EGF domain
Pathways
Biological processes and signaling networks where the Sparcl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- esophageal adenocarcinoma
- esophageal carcinoma formation
- colorectal adenoma
- colorectal adenoma formation
- corneal opacity
- bladder cancer
- uterine leiomyoma
- leiomyomatosis
- Alzheimer disease
regulates
- VEGF
- COL4
role in cell
- expression in
- formation
- growth
- proliferation
- invasion by
- differentiation
- migration
- organization
- density
- branching by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- endoplasmic reticulum lumen
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sparcl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- anatomical structure development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- collagen binding
- calcium ion binding