Adamts4 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity; protease binding activity; and zinc ion binding activity. Predicted to be involved in extracellular matrix organization and proteolysis. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular space and nuclear speck. Predicted to be active in extracellular matrix. Biomarker of degenerative disc disease and transient cerebral ischemia. Orthologous to human ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts4 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif, 4 [Source:RGD Symbol;Acc:621242] |
| Ensembl ID | ENSRNOG00000003538 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif, 4 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 4, ADAM metallopeptidase with thrombospondin type 1 motif, 4, ADAMS4, ADAMTS-2, ADMP-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamts4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 domain
- CD36-binding domain
- thrombospondin type 1 repeat
- ADAMTS cysteine-rich domain
- peptidase
- GAG-binding domain
- ADAM-TS Spacer 1
- zinc ion binding
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- furin cleavage consensus sequence
- cysteine rich domain
- Thrombospondin type 1 repeats
- Reprolysin family propeptide
- protease binding
- catalytic domain
- ADAMTS cysteine-rich domain 2
- protein binding
- disintergrin domain
- metallopeptidase
- ZnMc
- spacer domain
- Reprolysin (M12B) family zinc metalloprotease
- pro domain
- Spondin-like TSP1 domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adamts4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- cancer
- Alzheimer disease
- osteoarthritis
- diabetic nephropathy
- rheumatoid arthritis
- Ehlers-Danlos syndrome type VIIC
- Dupuytren contracture
- asthma
- hydronephrosis
role in cell
- quantity
- growth
- number
- morphology
- differentiation
- disassembly
- processing in
- branching
- branching in
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space
- intracellular storage compartment
- nuclear speckles
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamts4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- extracellular matrix disassembly
- proteolysis
- extracellular matrix organization
Cellular Component
Where in the cell the gene product is active
- extracellular space
- nuclear speck
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- protease binding
- peptidase activity
- metalloendopeptidase activity
- metallopeptidase activity