Skil Gene Summary [Rat]
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; SMAD binding activity; and identical protein binding activity. Involved in positive regulation of axonogenesis; response to cytokine; and spermatogenesis. Located in acrosomal vesicle. Biomarker of ureteral obstruction. Orthologous to human SKIL (SKI like proto-oncogene). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Skil |
| Official Name | SKI-like proto-oncogene [Source:RGD Symbol;Acc:621399] |
| Ensembl ID | ENSRNOG00000009899 |
| Bio databases IDs | |
| Aliases | SKI-like proto-oncogene |
| Synonyms | 9130011J04RIK, SKI-like, SKI-like proto-oncogene, SKIR, SNO, SnoA, SnoN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Skil often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- transcription regulator
- Sumoylation motif
- smad binding domain
- leucine zipper domain
- chromatin binding
- tandem repeat
- identical protein binding
- destruction box
- Family with sequence similarity 184, A and B
- c-SKI Smad4 binding domain
- Cell division protein ZapB
- TPR/MLP1/MLP2-like protein
- Domain of unknown function (DUF4515)
- nucleic acid binding
- oligomerization domain
- SKI/SNO/DAC family
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- MAP7 (E-MAP-115) family
- binding protein
- double-stranded DNA binding
- DHD_Ski_Sno_Dac
- Domain of unknown function (DUF4200)
Pathways
Biological processes and signaling networks where the Skil gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- prostate cancer
- cachexia
- metastasis
- epithelial cancer
- tinnitus
- papillomatosis
- epithelial neoplasia
- benign neoplasia
role in cell
- expression in
- proliferation
- transcription in
- binding in
- migration
- epithelial-mesenchymal transition
- growth
- apoptosis
- differentiation
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- acrosome
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Skil gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- spermatogenesis
- transforming growth factor beta receptor signaling pathway
- lymphocyte homeostasis
- DNA damage response, signal transduction resulting in induction of apoptosis
- induction of apoptosis via death domain receptors
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of BMP signaling pathway
- positive regulation of axonogenesis
- negative regulation of cell differentiation
- blastocyst formation
- regulation of cell cycle
- lens fiber cell differentiation
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- acrosomal vesicle
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- SMAD binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity