Adam15 Gene Summary [Rat]
Predicted to enable SH3 domain binding activity; metalloendopeptidase activity; and signaling receptor binding activity. Involved in male gonad development; response to hypobaric hypoxia; and tissue regeneration. Predicted to be located in cell surface and extracellular exosome. Predicted to be active in extracellular space. Orthologous to human ADAM15 (ADAM metallopeptidase domain 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam15 |
| Official Name | ADAM metallopeptidase domain 15 [Source:RGD Symbol;Acc:620402] |
| Ensembl ID | ENSRNOG00000020590 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 15 |
| Synonyms | AD56, ADAM metallopeptidase domain 15, MDC15, METARGIDIN, tMDCVI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reprolysin family propeptide
- ectodomain
- metalloprotease domain
- peptidase
- protein binding
- receptor binding
- disintergrin domain
- SH3-domain binding
- metallopeptidase
- ZnMc
- cytoplasmic domain
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- integrin binding
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- intracellular domain
- cytosolic tail domain
- disintegrin-like domain
- pro domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adam15 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- neoplasia
- colorectal neoplasm
- colorectal neoplasia
- laser induced choroidal neovascularization
- metastasis
- prostatic carcinoma
- prostate cancer
- epithelial cancer
- choroidal neovascularization
role in cell
- proliferation
- expression in
- growth
- apoptosis
- phosphorylation in
- migration
- aggregation
- adhesion
- hypertrophy
- attachment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- male gonad development
- extracellular matrix disassembly
- negative regulation of receptor binding
- cardiac epithelial to mesenchymal transition
- tissue regeneration
- integrin-mediated signaling pathway
- negative regulation of cell-matrix adhesion
- negative regulation of cell growth
- angiogenesis
- innate immune response
- immune response to tumor cell
- apoptotic process
- proteolysis
- collagen catabolic process
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- adherens junction
- motile cilium
- extracellular vesicular exosome
- acrosomal vesicle
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- integrin binding
- SH3 domain binding
- metalloendopeptidase activity
- immunoglobulin receptor binding
- metallopeptidase activity