Mak Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in several processes, including cilium organization; photoreceptor cell maintenance; and protein autophosphorylation. Predicted to act upstream of or within negative regulation of non-motile cilium assembly. Predicted to be located in several cellular components, including cytoskeleton; nuclear lumen; and photoreceptor cell cilium. Predicted to be active in cilium; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 62. Orthologous to human MAK (male germ cell associated kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mak |
| Official Name | male germ cell-associated kinase [Source:RGD Symbol;Acc:3036] |
| Ensembl ID | ENSRNOG00000015101 |
| Bio databases IDs | |
| Aliases | male germ cell-associated kinase |
| Synonyms | A930010O05Rik, male germ cell-associated kinase, Rck for protein kinase, RP62 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mak often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- transcription co-activator
- Protein tyrosine and serine/threonine kinase
- alcohol group acceptor phosphotransferase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinitis pigmentosa type 62
- retinitis pigmentosa
- retinal dystrophy
- prostate cancer
- major depression
- MAK-related retinopathy
- global developmental delay with intellectual disability
- asthenozoospermia
role in cell
- phosphorylation in
- motility
- degeneration
- assembly
- accumulation in
- acetylation in
- elongation
- stabilization in
- elongation in
- amplification in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- Nucleus
- Plasma Membrane
- basal bodies
- centrosome
- axonemes
- midbody
- cytosol
- connecting cilia
- nucleoplasm
- nucleoli
- photoreceptor outer segments
- photoreceptor inner segments
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mak gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- intraflagellar transport
- positive regulation of transcription, DNA-dependent
- spermatogenesis
- photoreceptor cell maintenance
- cell differentiation
- protein autophosphorylation
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- nucleus
- motile cilium
- centrosome
- mitotic spindle
- cytoplasm
- cilium
- midbody
- photoreceptor inner segment
- axoneme
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- transcription coactivator activity
- metal ion binding
- protein kinase activity
- protein serine/threonine kinase activity