Arl13b Gene Summary [Rat]
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including nervous system development; non-motile cilium assembly; and receptor localization to non-motile cilium. Predicted to act upstream of or within dorsal/ventral pattern formation; heart looping; and left/right axis specification. Predicted to be located in cytoskeleton; cytosol; and intercellular bridge. Predicted to be active in ciliary membrane; motile cilium; and non-motile cilium. Human ortholog(s) of this gene implicated in Joubert syndrome 8. Orthologous to human ARL13B (ARF like GTPase 13B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arl13b |
| Official Name | ADP-ribosylation factor like GTPase 13B [Source:RGD Symbol;Acc:1584979] |
| Ensembl ID | ENSRNOG00000047194 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor like GTPase 13B |
| Synonyms | A530097K21Rik, A930014M17Rik, ADP-ribosylation factor-like 13B, ARF like GTPase 13B, ARL2L1, C530009C10Rik, hnn, JBTS8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arl13b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- Ras family
- 50S ribosome-binding GTPase
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Joubert syndrome related disorder
- joubert syndrome type 8
- cancer
- brain cancer
- central nervous system cancer
- head and neck cancer
- head and neck neoplasia
- Joubert syndrome type 1
- hereditary disorder
- Joubert syndrome
role in cell
- expression in
- proliferation
- assembly
- number
- senescence
- length
- function
- degeneration
- downregulation in
- positioning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- motile cilia
- microtubule cytoskeleton
- cilia
- basal bodies
- axonemes
- cytoplasmic bridges
- cytosol
- primary cilia
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arl13b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- interneuron migration from the subpallium to the cortex
- heart looping
- smoothened signaling pathway
- formation of radial glial scaffolds
- left/right axis specification
- neural tube patterning
- dorsal/ventral pattern formation
Cellular Component
Where in the cell the gene product is active
- motile cilium
- cilium
- cytosol
- cilium membrane
- axoneme
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity