Ube2c Gene Summary [Rat]
Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin-like protein ligase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic cell cycle phase transition; and protein polyubiquitination. Predicted to be located in cytosol and plasma membrane. Predicted to be part of anaphase-promoting complex. Predicted to be active in nucleus. Orthologous to human UBE2C (ubiquitin conjugating enzyme E2 C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2c |
| Official Name | ubiquitin-conjugating enzyme E2C [Source:RGD Symbol;Acc:1305382] |
| Ensembl ID | ENSRNOG00000015131 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2C |
| Synonyms | 1110015A16Rik, CYCLIN-SELECTIVE UBIQUITIN CARRIER, D2Ertd695e, dJ447F3.2, E2c, UBCH10, UBIQUITIN CARRIER protein E2C, ubiquitin-conjugating enzyme E2C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ube2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- catalytic domain
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- enzyme binding
- UBCc_UEV
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2c gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- uterine cancer
- cancer
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- pancreatic cancer
- ovarian adenocarcinoma
- prostatic adenocarcinoma
role in cell
- migration
- degradation in
- cell death
- growth
- proliferation
- formation
- formation in
- survival
- morphology
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ube2c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- protein polyubiquitination
- positive regulation of mitotic metaphase/anaphase transition
- ubiquitin-dependent protein catabolic process
- cell division
- positive regulation of exit from mitosis
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- exit from mitosis
- free ubiquitin chain polymerization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- anaphase-promoting complex
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- protein binding
- small conjugating protein ligase binding