Eno2 Gene Summary [Rat]
Enables enzyme binding activity; identical protein binding activity; and phosphopyruvate hydratase activity. Involved in glucose metabolic process; response to estradiol; and response to xenobiotic stimulus. Located in several cellular components, including growth cone; membrane raft; and synaptic membrane. Part of phosphopyruvate hydratase complex. Biomarker of Parkinsonism and toxic shock syndrome. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ENO2 (enolase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eno2 |
| Official Name | enolase 2 [Source:RGD Symbol;Acc:2554] |
| Ensembl ID | ENSRNOG00000013141 |
| Bio databases IDs | |
| Aliases | enolase 2 |
| Synonyms | D6Ertd375e, enolase 2, enolase 2, gamma neuronal, enolase 2, γ neuronal, HEL-S-279, LOC100911625, NEURONAL-SPECIFIC ENOLASE, neuron specific γ enolase, NSE, RNEN3, γ enolase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eno2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enolase_like
- Enolase, C-terminal TIM barrel domain
- binding protein
- TIM-like beta/alpha barrel domains
- enzyme binding
- phosphopyruvate hydratase
- enzyme
- protein binding
- Enolase, N-terminal domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glaucoma
- organismal death
- Huntington disease
- early missed abortion
- Waldenström macroglobulinemia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- neuroendocrine gastroenteropancreatic tumor
- Parkinson disease
regulates
- SOD
role in cell
- glycolysis in
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- cell surface
- intracellular space
- cellular membrane
- cell cortex
- Plasma Membrane
- Mitochondria
- cytosol
- synaptic membrane
- synaptic vesicles
- growth cone
- photoreceptor inner segments
- membrane rafts
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eno2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- glycolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- cytosol
- perikaryon
- photoreceptor inner segment
- phosphopyruvate hydratase complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphopyruvate hydratase activity
- magnesium ion binding
- protein binding