Gem Gene Summary [Rat]
Predicted to enable several functions, including calcium channel regulator activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Predicted to be involved in chromosome organization; metaphase chromosome alignment; and mitotic cell cycle. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; midbody; and spindle. Predicted to be active in plasma membrane. Biomarker of glaucoma. Orthologous to human GEM (GTP binding protein overexpressed in skeletal muscle). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gem |
| Official Name | GTP binding protein overexpressed in skeletal muscle [Source:RGD Symbol;Acc:1307386] |
| Ensembl ID | ENSRNOG00000015160 |
| Bio databases IDs | |
| Aliases | GTP binding protein overexpressed in skeletal muscle |
| Synonyms | GTP binding protein OVEREXPRESSED IN SKELETAL MUSCLE, KIR, MMU10551 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gem often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- magnesium ion binding
- Ras subfamily of RAS small GTPases
- AAA domain
- GTP binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetic nephropathy
- autosomal dominant polycystic kidney disease
- uterine serous papillary cancer
- ulcerative colitis
- Marfan syndrome
- breast adenocarcinoma
- infection by equine herpesvirus 1
role in cell
- activation in
- apoptosis
- entrance
- elongation
- cell cycle progression
- growth
- invasion
- sprouting
- morphology
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Nucleus
- midbody
- cytoplasmic face of plasma membrane
- growth cone
- neurites
- dendritic trees
- filopodia
- central spindle
- mitotic spindle
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gem gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- metaphase plate congression
- immune response
- chromosome organization
- signal transduction
- cell surface receptor signaling pathway
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- spindle midzone
- mitotic spindle
- midbody
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- magnesium ion binding
- calmodulin binding
- protein binding
- GTPase activity
- GDP binding
- calcium channel regulator activity