Cacnb3 Gene Summary [Rat]
Enables calcium channel regulator activity; protein kinase binding activity; and voltage-gated calcium channel activity. Involved in several processes, including calcium ion transmembrane transport; regulation of nervous system process; and regulation of voltage-gated calcium channel activity. Located in apical plasma membrane. Part of L-type voltage-gated calcium channel complex. Orthologous to human CACNB3 (calcium voltage-gated channel auxiliary subunit beta 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacnb3 |
| Official Name | calcium voltage-gated channel auxiliary subunit beta 3 [Source:RGD Symbol;Acc:2248] |
| Ensembl ID | ENSRNOG00000054274 |
| Bio databases IDs | |
| Aliases | calcium voltage-gated channel auxiliary subunit beta 3 |
| Synonyms | Beta3, CAB3, CACH3B, CACNLB3, Calcium Channel beta3, calcium channel, voltage-dependent, beta 3 subunit, calcium channel, voltage-dependent, β 3 subunit, calcium voltage-gated channel auxiliary subunit beta 3, calcium voltage-gated channel auxiliary subunit β 3, Ca(v)beta3, Cchb3, Voltage gated calcium channel beta subunit, Voltage gated calcium channel β subunit |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cacnb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanylate kinase
- voltage-gated calcium channel
- protein kinase binding
- NK
- high voltage-gated calcium channel
- Voltage gated calcium channel subunit beta domain 4Aa N terminal
- protein binding
- ion channel
- calcium channel regulator
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Cacnb3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Androgen Signaling
- Calcium Signaling
- Cardiac β-adrenergic Signaling
- CCR5 Signaling in Macrophages
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- FcγRIIB Signaling in B Lymphocytes
- G Beta Gamma Signaling
- GABA Receptor Signaling
- GNRH Signaling
- GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells
- Gustation Pathway
- Maturity Onset Diabetes of Young (MODY) Signaling
- Netrin Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- nNOS Signaling in Skeletal Muscle Cells
- PKCθ Signaling in T Lymphocytes
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- hypertension
- arrhythmia
- hypoglycemia
- obesity
- variant angina
- ischemic cardiomyopathy
- Wolff-Parkinson-White syndrome
- paroxysmal supraventricular tachycardia
- COVID-19
role in cell
- migration
- expression in
- growth
- survival
- function
- transport in
- long-term potentiation
- depletion in
- detachment
- innervation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cellular membrane
- cytosol
- apical membrane
- microsomal membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cacnb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuromuscular junction development
- calcium ion transport
- synaptic transmission
- T cell receptor signaling pathway
- protein localization in plasma membrane
- calcium ion transport into cytosol
Cellular Component
Where in the cell the gene product is active
- membrane
- voltage-gated calcium channel complex
- cytosol
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- high voltage-gated calcium channel activity
- calcium channel regulator activity
- voltage-gated calcium channel activity