Spsb3 Gene Summary [Rat]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human SPSB3 (splA/ryanodine receptor domain and SOCS box containing 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spsb3 |
| Official Name | splA/ryanodine receptor domain and SOCS box containing 3 [Source:RGD Symbol;Acc:1310936] |
| Ensembl ID | ENSRNOG00000015300 |
| Bio databases IDs | |
| Aliases | splA/ryanodine receptor domain and SOCS box containing 3 |
| Synonyms | 2310012N15Rik, 3300001M01Rik, C16ORF31, mKIAA4204, splA/ryanodine receptor domain and SOCS box containing 3, SSB3, Tce1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spsb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- SPRY domain
- protein binding activity, bridging
- SOCS
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by human herpesvirus 1
- infection by vaccinia virus
regulated by
- phenethyl isothiocyanate
- n-nitrosomethylbenzylamine
- black raspberry extract
role in cell
- expression in
- ubiquitination in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spsb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding