Numbl Gene Summary [Rat]
Involved in positive regulation of dendrite morphogenesis and regulation of postsynapse assembly. Is active in glutamatergic synapse. Orthologous to human NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Numbl |
| Official Name | NUMB-like, endocytic adaptor protein [Source:RGD Symbol;Acc:1307579] |
| Ensembl ID | ENSRNOG00000020867 |
| Bio databases IDs | |
| Aliases | NUMB-like, endocytic adaptor protein |
| Synonyms | CAG3A, CTG3a, NBL, NUMBLIKE, NUMB like endocytic adaptor protein, NUMB-like, endocytic adaptor protein, NUMB-R, TNRC23 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Numbl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NUMB domain
- phenylalanine rich domain
- NPF motif
- coiled-coil domain
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
Pathways
Biological processes and signaling networks where the Numbl gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- COVID-19
- organismal death
- hepatocellular carcinoma
- liver cancer
- lung carcinoma
- lung carcinoma process
- lung adenocarcinoma
- lung adenocarcinoma formation
- nicotine dependence
role in cell
- expression in
- phosphorylation in
- proliferation
- differentiation
- binding in
- accumulation in
- invasion
- quantity
- maturation
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- Nucleus
- cytosol
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Numbl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuroblast division in subventricular zone
- protein metabolic process
- lateral ventricle development
- adherens junction organization
- cytokine-mediated signaling pathway
- axonogenesis
- nervous system development
- positive regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding