Isl2 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in axonogenesis; neuron fate specification; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of neuron differentiation and neuron differentiation. Predicted to be active in nucleus. Orthologous to human ISL2 (ISL LIM homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Isl2 |
| Official Name | ISL LIM homeobox 2 [Source:RGD Symbol;Acc:621849] |
| Ensembl ID | ENSRNOG00000015336 |
| Bio databases IDs | |
| Aliases | ISL LIM homeobox 2 |
| Synonyms | 3110001N10Rik, insulin related protein 2 (islet 2), ISL LIM homeobox 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Isl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sleep apnea syndrome
role in cell
- differentiation
- quantity
- development
- abnormal morphology
- guidance
- innervation
- commitment
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Isl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinal ganglion cell axon guidance
- neuron fate specification
- axonogenesis
- negative regulation of neuron differentiation
- visceral motor neuron differentiation
- neuron development
- positive regulation of transcription from RNA polymerase II promoter
- peripheral nervous system neuron development
- spinal cord motor neuron cell fate specification
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity