Heatr3 Gene Summary [Rat]
Predicted to enable unfolded protein binding activity. Predicted to be involved in erythrocyte maturation; protein import into nucleus; and ribosomal large subunit biogenesis. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia. Orthologous to human HEATR3 (HEAT repeat containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Heatr3 |
| Official Name | HEAT repeat containing 3 [Source:RGD Symbol;Acc:1308267] |
| Ensembl ID | ENSRNOG00000015459 |
| Bio databases IDs | |
| Aliases | HEAT repeat containing 3 |
| Synonyms | C030036P15Rik, DBA21, HEAT repeat containing 3, RGD1308267, SYO1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Heatr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT-like repeat
- Fungal symportin 1 (syo1) and similar proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial neoplasia
- Diamond-Blackfan anemia type 21
- uterine leiomyoma
- leiomyomatosis
- diamond blackfan anemia type 1
- liver cancer
- epithelial cancer
- cholangiocarcinoma cancer
- bile duct cancer
regulates
- ribosomal large subunit
role in cell
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Heatr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosomal large subunit biogenesis
- protein import into nucleus
- erythrocyte maturation
Molecular Function
What the gene product does at the molecular level
- unfolded protein binding