Chrm4 Gene Summary [Rat]
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; and chemical synaptic transmission. Located in several cellular components, including asymmetric synapse; neuronal cell body; and sarcolemma. Is active in glutamatergic synapse; postsynaptic density membrane; and presynaptic membrane. Biomarker of congestive heart failure. Orthologous to human CHRM4 (cholinergic receptor muscarinic 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrm4 |
| Official Name | cholinergic receptor, muscarinic 4 [Source:RGD Symbol;Acc:2344] |
| Ensembl ID | ENSRNOG00000017556 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, muscarinic 4 |
| Synonyms | AChR M4, CHOLINERGIC receptor MUSCARINIC 4, cholinergic receptor, muscarinic 4, HM4, M4, M4 machr, M4 MUSCARINIC receptor, M4R, mm4 mAChR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Chrm4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled acetylcholine receptor
- intracellular loop
- CaMKII binding domain
- guanyl-nucleotide exchange factor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Chrm4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- pain
- diarrhea
- cancer
- vomiting
- chronic obstructive pulmonary disease
- bipolar I disorder
- alcoholism
- depressive disorder
- asthma
role in cell
- production in
- phosphorylation in
- migration
- transmission
- transmission in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- postsynaptic region
- cellular membrane
- presynaptic membrane
- synaptic membrane
- synapse
- sarcolemma
- perikaryon
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Chrm4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- regulation of locomotion
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- signal transduction
- synaptic transmission
- G-protein coupled acetylcholine receptor signaling pathway
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic membrane
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity