Nsd3 Gene Summary [Rat]
Predicted to enable protein-lysine N-methyltransferase activity and transcription regulator activator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in myeloid leukemia. Orthologous to human NSD3 (nuclear receptor binding SET domain protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nsd3 |
| Official Name | nuclear receptor binding SET domain protein 3 [Source:RGD Symbol;Acc:1308980] |
| Ensembl ID | ENSRNOG00000015621 |
| Bio databases IDs | |
| Aliases | nuclear receptor binding SET domain protein 3 |
| Synonyms | 6720429E03, A530023P05, KMT3F, KMT3G, nuclear receptor binding SET domain protein 3, pp14328, WHISTLE, WHSC1L1, Wolf-Hirschhorn syndrome candidate 1-like 1 protein homolog |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nsd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- AWS domain
- PWWP domain
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- histone lysine N-methyltransferase activity (H3-K27 specific)
- histone lysine N-methyltransferase activity (H3-K4 specific)
- associated with SET domains
- histone methyltransferase
- histone lysine N-methyltransferase activity (H3-K36 specific)
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- PHD finger superfamily
- NSD Cys-His rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung squamous cell carcinoma
- squamous cell lung cancer
- organismal death
- breast cancer
- preeclampsia
- survival
- lung adenocarcinoma
- lung adenocarcinoma formation
- Tourette syndrome
regulated by
- BRD4
- beta-estradiol
- trichostatin A
- SP2509
- decitabine
- long-term hematopoietic stem cells
- STAT4
- tazemetostat
- histone H3
role in cell
- expression in
- migration
- morphology
- invasion by
- transactivation in
- somatic cell reprogramming
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nsd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- histone methyltransferase activity (H3-K36 specific)