Spred1 Gene Summary [Rat]
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Spred1 |
| Official Name | sprouty-related, EVH1 domain containing 1 [Source:RGD Symbol;Acc:1308735] |
| Ensembl ID | ENSRNOG00000005209 |
| Bio databases IDs | |
| Aliases | sprouty-related, EVH1 domain containing 1 |
| Synonyms | 5730461F13Rik, hSpred1, LGSS, NFLS, PPP1R147, sprouty protein with EVH-1 domain 1, related sequence, sprouty related EVH1 domain containing 1, sprouty-related, EVH1 domain containing 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spred1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stem cell factor receptor binding
- protein kinase binding
- protein serine/threonine kinase inhibitor
- kinase interacting domain
- EVH1 domain
- protein binding
- Pleckstrin homology-like domain
- zDHHC ankyrin repeat binding domain
- cysteine rich domain
- Sprouty protein (Spry)
- phosphatase binding
Pathways
Biological processes and signaling networks where the Spred1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Neurofibromatosis type 1-like syndrome
- edema
- vascular leak syndrome
- idiopathic scoliosis
- bleeding
- hereditary disorder
- cutaneous melanoma cancer
- neurofibromatosis 1
- airway hyperresponsiveness
role in cell
- phosphorylation in
- production in
- proliferation
- differentiation
- quantity
- number
- growth
- binding in
- function
- excitatory postsynaptic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- cytosol
- nucleoplasm
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Spred1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- regulation of MAPK cascade
- positive regulation of DNA damage response, signal transduction by p53 class mediator
- regulation of protein deacetylation
- negative regulation of MAPK cascade
- vasculogenesis involved in coronary vascular morphogenesis
- negative regulation of cell migration involved in sprouting angiogenesis
- negative regulation of protein kinase activity
- negative regulation of epithelial to mesenchymal transition
- negative regulation of peptidyl-threonine phosphorylation
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- caveola
- cytoplasmic vesicle
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein kinase binding
- protein serine/threonine kinase inhibitor activity
- protein binding
- stem cell factor receptor binding