Dot1l

Predicted to enable several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; histone H3K79 methyltransferase activity; and transcription coactivator activity. Predicted to be involved in several processes, including DNA damage checkpoint signaling; regulation of receptor signaling pathway via JAK-STAT; and subtelomeric heterochromatin formation. Predicted to act upstream of or within with a negative effect on gene expression. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in acute biphenotypic leukemia. Orthologous to human DOT1L (DOT1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dot1l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Dot1l gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Dot1l gene, providing context for its role in the cell.