B4galt6 Gene Summary [Rat]
Enables UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity. Involved in glycosphingolipid biosynthetic process. Predicted to be located in Golgi cisterna membrane and Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT6 (beta-1,4-galactosyltransferase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | B4galt6 |
| Official Name | beta-1,4-galactosyltransferase 6 [Source:RGD Symbol;Acc:71046] |
| Ensembl ID | ENSRNOG00000015895 |
| Bio databases IDs | |
| Aliases | beta-1,4-galactosyltransferase 6 |
| Synonyms | beta-1,4-galactosyltransferase 6, beta4Gal-T6, Galt-2, LacCer Synthase, UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6, UDP-Gal:betaGlcNAc β 1,4-galactosyltransferase, polypeptide 6, β-1,4-galactosyltransferase 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat B4galt6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UDP-galactose-glucosylceramide beta-1,4-galactosyltransferase
- galactosyltransferase
- N-terminal domain of galactosyltransferase
- N-terminal region of glycosyl transferase group 7
- enzyme
- protein binding
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- multiple sclerosis
role in cell
- recruitment
- expression in
- proliferation
- maturation
- function
- depletion in
- axonogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat B4galt6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycosylation
- central nervous system myelination
- ganglioside biosynthetic process via lactosylceramide
- carbohydrate metabolic process
- central nervous system neuron axonogenesis
- protein glycosylation
- neuron maturation
- glycosphingolipid biosynthetic process
- lactosylceramide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity
- galactosyltransferase activity