Hoxc10 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic limb morphogenesis; regionalization; and spinal cord motor neuron cell fate specification. Predicted to be located in nuclear body. Predicted to be active in nucleus. Orthologous to human HOXC10 (homeobox C10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hoxc10 |
| Official Name | homeo box C10 [Source:RGD Symbol;Acc:1307250] |
| Ensembl ID | ENSRNOG00000016149 |
| Bio databases IDs | |
| Aliases | homeo box C10 |
| Synonyms | AI506621, homeo box C10, Hox-3.6, HOX3I |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hoxc10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast carcinoma
- renal cancer
- metastasis
- organismal death
- Cornelia de Lange syndrome
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- phosphorylation in
- migration
- expression in
- proliferation
- cell viability
- growth
- damage in
- recruitment in
- transactivation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hoxc10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic limb morphogenesis
- skeletal system development
- positive regulation of cell proliferation
- neuromuscular process
- anterior/posterior pattern specification
- positive regulation of transcription from RNA polymerase II promoter
- spinal cord motor neuron cell fate specification
- proximal/distal pattern formation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity