Adam17 Gene Summary [Rat]
Predicted to enable several functions, including PDZ domain binding activity; metallopeptidase activity; and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of ERK1 and ERK2 cascade; and regulation of apoptotic process. Located in apical part of cell and cell surface. Biomarker of Alzheimer's disease; congestive heart failure; and thoracic aortic aneurysm. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adam17 |
| Official Name | ADAM metallopeptidase domain 17 [Source:RGD Symbol;Acc:620404] |
| Ensembl ID | ENSRNOG00000060694 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase domain 17 |
| Synonyms | ADAM18, ADAM metallopeptidase domain 17, a disintegrin and metallopeptidase domain 17, Alpha Secretase, CD156B, CSVP, NISBD, NISBD1, TACE, TNFA CONVERTASE, Tnf-α-converting enzyme, tumor necrosis factor, α, converting enzyme, tumour necrosis factor, alpha, converting enzyme, tumour necrosis factor, α, converting enzyme, α Secretase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adam17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine binding
- metalloprotease domain
- peptidase
- Membrane-proximal domain of a disintegrin and metalloprotease 17 (ADAM17)
- inhibitory domain
- enzyme
- zinc binding domain
- cytoplasmic domain
- interleukin-6 receptor binding
- Metallo-peptidase family M12B Reprolysin-like
- cysteine rich domain
- extracellular domain
- Reprolysin family propeptide
- metalloexopeptidase
- catalytic domain
- dipeptidase
- ectodomain
- protein binding
- EGF-like domain
- disintergrin domain
- PDZ-domain binding
- Myxococcus cysteine-rich repeat
- metallopeptidase
- ZnMc
- endopeptidase
- serine endopeptidase
- integrin binding
- transmembrane domain
- Disintegrin
- Reprolysin (M12B) family zinc metalloprotease
- cytosolic tail domain
- pro domain
- metalloendopeptidase
- notch binding
Pathways
Biological processes and signaling networks where the Adam17 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- ErbB4 Signaling
- Inhibition of Matrix Metalloproteases
- Neuregulin Signaling
- Notch Signaling
- RAR Activation
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alcoholism
- atopic dermatitis
- neoplasia
- metastasis
- epithelial cancer
- cancer
- acute pancreatitis
- pneumonitis
- myeloproliferative disorder
- nuchal edema
role in cell
- migration
- apoptosis
- number
- cell viability
- expression in
- production in
- outgrowth
- cell death
- proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- vesicular element
- discoidal-fusiform vesicle
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- focal adhesions
- actin cytoskeleton
- Endoplasmic Reticulum
- intercellular junctions
- cytosol
- apical cell surfaces
- endoplasmic reticulum lumen
- membrane ruffles
- apical membrane
- Golgi membrane
- perinuclear space
- membrane rafts
- membrane processes
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adam17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell proliferation
- positive regulation of epidermal growth factor receptor signaling pathway
- spleen development
- cell adhesion
- response to xenobiotic stimulus
- positive regulation of epidermal growth factor-activated receptor activity
- positive regulation of cell growth
- response to hypoxia
- signal release
- positive regulation of tumor necrosis factor production
- positive regulation of chemokine production
- wound healing, spreading of epidermal cells
- defense response to Gram-positive bacterium
- commissural neuron axon guidance
- amyloid precursor protein catabolic process
- positive regulation of cyclin-dependent protein kinase activity
- B cell differentiation
- positive regulation of G1/S transition of mitotic cell cycle
- Notch receptor processing
- T cell differentiation in thymus
- positive regulation of leukocyte chemotaxis
- positive regulation of blood vessel endothelial cell migration
- cell motility
- germinal center formation
- cell adhesion mediated by integrin
- neutrophil mediated immunity
- Notch signaling pathway
- membrane protein ectodomain proteolysis
- proteolysis
- positive regulation of T cell chemotaxis
- cellular response to high density lipoprotein particle stimulus
- response to lipopolysaccharide
- protein processing
- regulation of mast cell apoptotic process
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- plasma membrane
- cell surface
- endoplasmic reticulum lumen
- cell-cell junction
- focal adhesion
- cytoplasm
- membrane raft
- membrane
- actin cytoskeleton
- ruffle membrane
- cytosol
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- endopeptidase activity
- integrin binding
- Notch binding
- peptidase activity
- metalloendopeptidase activity
- interleukin-6 receptor binding
- metallopeptidase activity
- protein binding
- metal ion binding
- tumor necrosis factor binding
- PDZ domain binding
- SH3 domain binding
- cytokine binding