Sgcb Gene Summary [Rat]
Predicted to be involved in muscle organ development. Predicted to act upstream of or within several processes, including glucose import in response to insulin stimulus; muscle cell development; and response to glucose. Predicted to be located in plasma membrane. Predicted to be part of sarcoglycan complex. Predicted to be active in sarcolemma. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2E and muscular dystrophy. Orthologous to human SGCB (sarcoglycan beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgcb |
| Official Name | sarcoglycan, beta [Source:RGD Symbol;Acc:1594202] |
| Ensembl ID | ENSRNOG00000002135 |
| Bio databases IDs | |
| Aliases | sarcoglycan, beta |
| Synonyms | 43DAG, A3b, AI844814, Beta sacroglycan, beta SARCOGLYCAN, beta-SG, LGMD2E, LGMDR4, LOC687025, sarcoglycan beta, sarcoglycan, beta, sarcoglycan, beta (dystrophin-associated glycoprotein), Sarcoglycan β, sarcoglycan, β, sarcoglycan, β (dystrophin-associated glycoprotein), SGC, β sacroglycan, β SARCOGLYCAN, β-SG |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sgcb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intracellular domain
- Sarcoglycan complex subunit protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- limb-girdle muscular dystrophy type 2E
- cardiomyopathy
- hereditary disorder
- muscular dystrophy
- limb-girdle muscular dystrophy type 2
- weight gain
- sialidosis
- myositis
- primary dilated cardiomyopathy
- impaired glucose tolerance
role in cell
- necrosis
- organization
- abnormal morphology
- integrity
- development
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- endoplasmic reticulum membrane
- microsome
- Golgi membrane
- synapse
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sgcb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- response to glucose stimulus
- glucose import in response to insulin stimulus
- glucose homeostasis
- cardiac muscle cell development
- gene expression
- vascular smooth muscle cell development
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytoplasm
- sarcolemma
- dystrophin-associated glycoprotein complex
- sarcoglycan complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding