Frrs1 Gene Summary [Rat]
Predicted to enable oxidoreductase activity, acting on metal ions. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be active in membrane. Orthologous to human FRRS1 (ferric chelate reductase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frrs1 |
| Official Name | ferric-chelate reductase 1 [Source:RGD Symbol;Acc:1306883] |
| Ensembl ID | ENSRNOG00000016351 |
| Bio databases IDs | |
| Aliases | ferric-chelate reductase 1 |
| Synonyms | ferric-chelate reductase 1, SDFR2, SDR-2, Stromal cell derived factor receptor 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Frrs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domon-like ligand-binding domains
- metal ion oxidising oxidoreductase
- Reeler domain
- Domains similar to the eukaryotic reeler domain and bacterial cohesins
- Cytochrome_b_N
- DOMON domain
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Alzheimer disease
- glioblastoma
- glioblastoma cancer
- dilated cardiomyopathy
- monoclonal gammopathy of undertermined significance
- squamous-cell carcinoma
- squamous cell cancer
- ulcerative colitis
- astrocytoma
regulates
- iron ion
role in cell
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Frrs1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity, oxidizing metal ions
- metal ion binding