Apba2 Gene Summary [Rat]
Enables amyloid-beta binding activity. Predicted to be involved in chemical synaptic transmission and presynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within in utero embryonic development; locomotory behavior; and regulation of gene expression. Is active in presynapse. Orthologous to human APBA2 (amyloid beta precursor protein binding family A member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apba2 |
| Official Name | amyloid beta precursor protein binding family A member 2 [Source:RGD Symbol;Acc:620845] |
| Ensembl ID | ENSRNOG00000016358 |
| Bio databases IDs | |
| Aliases | amyloid beta precursor protein binding family A member 2 |
| Synonyms | amyloid beta precursor protein binding family A member 2, amyloid β precursor protein binding family A member 2, D15S1518E, HsT16821, LIN-10, MGC:14091, MINT2, mXllL, X11-BETA, X11L, X11-like, X11-β, XllL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Apba2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- munc-18 binding domain
- canonical PDZ domain
- beta-amyloid binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- PDZ domain
- cpPDZ_Deg_HtrA-like
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- pervasive developmental disorder
- schizophrenia
- Klinefelter syndrome
- ataxia
- adenoid cystic carcinoma
- Turner syndrome
- abnormality of the integument
- SAPHO syndrome
- overall survival
role in cell
- binding in
- activity
- formation
- outgrowth
- transmission
- outgrowth in
- paired-pulse facilitation
- accumulation in
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- presynaptic regions
- perinuclear region
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- trans face of the Golgi apparatus
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Apba2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- locomotory behavior
- in utero embryonic development
- protein transport
- regulation of gene expression
- nervous system development
- synaptic transmission
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- dendritic spine
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- beta-amyloid binding