Lrp8 Gene Summary [Rat]
Enables high-density lipoprotein particle binding activity and kinesin binding activity. Involved in several processes, including cellular response to cholesterol; cellular response to growth factor stimulus; and cerebral cortex development. Located in axon; dendrite; and neuronal cell body. Part of microtubule associated complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrp8 |
| Official Name | LDL receptor related protein 8 [Source:RGD Symbol;Acc:1305729] |
| Ensembl ID | ENSRNOG00000013064 |
| Bio databases IDs | |
| Aliases | LDL receptor related protein 8 |
| Synonyms | 4932703M08Rik, AI848122, APOER2, HSZ75190, LDL receptor related protein 8, low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, LR8B, MCI1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lrp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- O-linked glycosylation site
- high-density lipoprotein binding
- signal peptide
- NHL repeat unit of beta-propeller proteins
- proline rich domain
- EGF_CA
- NPXY motif
- cytoplasmic domain
- ligand-binding domain
- furin cleavage consensus sequence
- intracellular domain
- LDLa
- transmembrane receptor
- Coagulation Factor Xa inhibitory site
- calcium-dependent protein binding
- extracellular domain
- ligand binding repeat
- ectodomain
- protein binding
- Low-density lipoprotein receptor repeat class B
- very-low-density lipoprotein receptor
- beta-amyloid binding
- LDL-binding domain 1
- EGF-like domain
- kinesin binding
- transmembrane domain
- EGF domain
- cytosolic tail domain
- low-density lipoprotein receptor
- Low-density lipoprotein-receptor YWTD domain
Pathways
Biological processes and signaling networks where the Lrp8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- K/BxN serum transfer arthritis
- hydrocephalus
- group 3 medulloblastoma
- brain cancer
- irritable bowel syndrome
- diminished ovarian reserve
- colon epithelial cancer
- diabetic nephropathy
- tremor
role in cell
- expression in
- migration
- apoptosis
- growth
- colony formation by
- differentiation
- activation in
- adhesion
- formation
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- vesicles
- postsynaptic membrane
- caveolae
- synaptic membrane
- growth cone
- synapse
- membrane rafts
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lrp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reelin-mediated signaling pathway
- positive regulation of dendritic spine morphogenesis
- layer formation in cerebral cortex
- signal transduction
- ventral spinal cord development
- synaptic transmission
- regulation of apoptotic process
- response to xenobiotic stimulus
- endocytosis
- ammon gyrus development
- positive regulation of dendrite development
- dendrite morphogenesis
- retinoid metabolic process
- cellular response to growth factor stimulus
- cytokine-mediated signaling pathway
- proteolysis
- cellular response to cholesterol
- lipid metabolic process
- regulation of innate immune response
- regulation of synaptic transmission
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- caveola
- extracellular space
- membrane
- receptor complex
- neuronal cell body
- synapse
- axon
- microtubule associated complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- apolipoprotein binding
- reelin receptor activity
- cargo receptor activity
- low-density lipoprotein receptor activity
- calcium-dependent protein binding
- high-density lipoprotein particle binding
- beta-amyloid binding
- protein binding
- very-low-density lipoprotein particle receptor activity
- transmembrane signaling receptor activity
- calcium ion binding
- kinesin binding