Ccl22 Gene Summary [Rat]
Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide. Predicted to be located in extracellular space. Used to study anti-basement membrane glomerulonephritis. Biomarker of asthma; pneumonia; and pulmonary fibrosis. Orthologous to human CCL22 (C-C motif chemokine ligand 22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl22 |
| Official Name | C-C motif chemokine ligand 22 [Source:RGD Symbol;Acc:619933] |
| Ensembl ID | ENSRNOG00000016535 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 22 |
| Synonyms | A-152E5.1, ABCD-1, C-C motif chemokine ligand 22, DCBCK, DC/B-CK, Macrophage Chemotactic Protein 1, MDC, SCYA22, STCP-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccl22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Ccl22 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allodynia
- infection
- atopic dermatitis
- systemic lupus erythematosus
- proteinuria
- neoplasia
- insulin-dependent diabetes mellitus
- liver disease
- rheumatoid arthritis
- chronic natural killer lymphoproliferative disorder
role in cell
- expression in
- activity
- activation in
- migration
- phosphorylation in
- chemotaxis
- activation
- adhesion
- binding
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccl22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemotaxis
- inflammatory response
- immune response
- signal transduction
- eosinophil chemotaxis
- chemokine-mediated signaling pathway
- cell-cell signaling
- response to virus
- positive regulation of GTPase activity
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- CCR chemokine receptor binding
- protein binding
- chemokine activity