Use1 Gene Summary [Rat]
Predicted to enable SNAP receptor activity. Predicted to be involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within endoplasmic reticulum tubular network organization and regulation of ER to Golgi vesicle-mediated transport. Located in COPI-coated vesicle. Part of SNARE complex. Orthologous to human USE1 (unconventional SNARE in the ER 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Use1 |
| Official Name | unconventional SNARE in the ER 1 [Source:RGD Symbol;Acc:1306660] |
| Ensembl ID | ENSRNOG00000016619 |
| Bio databases IDs | |
| Aliases | unconventional SNARE in the ER 1 |
| Synonyms | 2010315L10Rik, 5730403H22Rik, D12, Ed2, LOC499392, MDS032, mED2, P31, Q-snare, RGD1306660, SLT1, unconventional SNARE in the ER 1, unconventional SNARE in the ER 1 homolog (S. cerevisiae) |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Use1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transmembrane domain
- protein binding
- Membrane fusion protein Use1
- SNARE motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
role in cell
- upregulation in
- expression in
- apoptosis
- growth
- replication in
- disorganization
- disorganization in
- phagocytosis
- vesiculation
- vesiculation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Use1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- membrane fusion
- retrograde vesicle-mediated transport, Golgi to ER
- lysosomal transport
- protein catabolic process
- protein transport
- secretion by cell
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- SNARE complex
- endoplasmic reticulum
- lysosome
- COPI-coated vesicle
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity