Cox5b Gene Summary [Rat]
Predicted to enable cytochrome-c oxidase activity. Involved in response to peptide hormone and response to thyroid hormone. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrial inner membrane. Biomarker of hypertension. Orthologous to human COX5B (cytochrome c oxidase subunit 5B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cox5b |
| Official Name | cytochrome c oxidase subunit 5B [Source:RGD Symbol;Acc:620608] |
| Ensembl ID | ENSRNOG00000016660 |
| Bio databases IDs | |
| Aliases | cytochrome c oxidase subunit 5B |
| Synonyms | COXVB, cytochrome c oxidase subunit 5B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cox5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome-c oxidase
- enzyme
- protein binding
- Cyt_c_Oxidase_Vb
Pathways
Biological processes and signaling networks where the Cox5b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- Huntington disease
- insulin resistance
- androgenic alopecia
- nonalcoholic steatohepatitis
- chromophobe renal cell carcinoma
- chromophobe renal cancer
role in cell
- activation in
- expression in
- growth
- invasion
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- mitochondrial fraction
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cox5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial electron transport, cytochrome c to oxygen
- cellular respiration
- respiratory gaseous exchange
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrion
- mitochondrial respiratory chain complex IV
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytochrome-c oxidase activity
- metal ion binding