Capn6 Gene Summary [Rat]
Predicted to enable microtubule binding activity. Predicted to be involved in microtubule bundle formation and regulation of cytoskeleton organization. Predicted to be located in perinuclear region of cytoplasm and spindle microtubule. Predicted to be active in cytoplasm. Biomarker of hypertension. Orthologous to human CAPN6 (calpain 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Capn6 |
| Official Name | calpain 6 [Source:RGD Symbol;Acc:70960] |
| Ensembl ID | ENSRNOG00000004882 |
| Bio databases IDs | |
| Aliases | calpain 6 |
| Synonyms | calpain 6, CalpM, CANPX, CAPNX, DJ914P14.1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Capn6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Calpain family cysteine protease
- calpain
- peptidase
- protein binding
- Calpain_III
- CysPc
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Pathways
Biological processes and signaling networks where the Capn6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- infection by HIV-1
- endometriosis
- diabetic nephropathy
- uterine leiomyoma
- leiomyomatosis
- leiomyoma
role in cell
- expression in
- proliferation
- apoptosis
- formation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- microtubules
- spindle fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Capn6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule bundle formation
- regulation of cytoskeleton organization
- proteolysis
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
- perinuclear region of cytoplasm
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium-dependent cysteine-type endopeptidase activity
- microtubule binding