Kcnn2 Gene Summary [Rat]
Enables calmodulin binding activity and small conductance calcium-activated potassium channel activity. Involved in positive regulation of potassium ion transport; potassium ion transport; and regulation of neuronal synaptic plasticity. Located in dendritic spine; membrane; and neuronal cell body. Used to study essential tremor. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in myoclonic dystonia 34. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnn2 |
| Official Name | potassium calcium-activated channel subfamily N member 2 [Source:RGD Symbol;Acc:2963] |
| Ensembl ID | ENSRNOG00000016675 |
| Bio databases IDs | |
| Aliases | potassium calcium-activated channel subfamily N member 2 |
| Synonyms | bc, DYT34, fri, hSK2, KCa2.2, LOC100910229, LOC101927041, LOC103690147, NEDMAB, potassium calcium-activated channel subfamily N member 2, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, SK2, SKCA2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated SK potassium channel
- inward rectifier potassium channel
- calmodulin binding
- small conductance calcium-activated potassium channel
- actinin binding
- calmodulin binding domain
- calcium-activated potassium channel
- alpha helix
- protein domain specific binding
- protein binding
- ion channel
- Prefoldin subunit
- prefoldin
- protein homodimerization
- cytosolic tail domain
- loop domain
Pathways
Biological processes and signaling networks where the Kcnn2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- hereditary disorder
- atrial fibrillation
- coronary aneurysm
- hepatocellular carcinoma
- Alzheimer disease
- cardioembolic stroke
- neurodevelopmental disorder with or without variable movement or behavioral abnormalities
- bipolar disorder
regulates
- K+
role in cell
- action potential
- excitation
- excitability
- plasticity
- intrinsic neuronal plasticity
- afterhyperpolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- intramembrane particles
- postsynaptic membrane
- dendritic spines
- synaptic vesicles
- sarcolemma
- Z line
- smooth endoplasmatic reticulum
- transverse tubules
- perikaryon
- dendritic branches
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- Z disc
- dendritic spine
- membrane
- neuronal cell body
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- calcium-activated potassium channel activity
- protein domain specific binding
- calmodulin binding
- protein homodimerization activity
- protein binding
- inward rectifier potassium channel activity
- small conductance calcium-activated potassium channel activity
- alpha-actinin binding