Kcnn2

Enables small conductance calcium-activated potassium channel activity. Involved in membrane repolarization during atrial cardiac muscle cell action potential; modulation of chemical synaptic transmission; and potassium ion transmembrane transport. Located in several cellular components, including T-tubule; Z disc; and smooth endoplasmic reticulum. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in brain; heart; and heart ventricle. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in myoclonic dystonia 34. Orthologous to human KCNN2 (potassium calcium-activated channel subfamily N member 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Kcnn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnn2 gene, providing context for its role in the cell.