Wnk2 Gene Summary [Rat]
Predicted to enable potassium channel inhibitor activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including protein autophosphorylation; regulation of metal ion transport; and regulation of signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Biomarker of transient cerebral ischemia. Orthologous to human WNK2 (WNK lysine deficient protein kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wnk2 |
| Official Name | WNK lysine deficient protein kinase 2 [Source:RGD Symbol;Acc:1307284] |
| Ensembl ID | ENSRNOG00000016684 |
| Bio databases IDs | |
| Aliases | WNK lysine deficient protein kinase 2 |
| Synonyms | 1810073P09RIK, ESTM15, LOC105376151, mKIAA1760, NY-CO-43, P/OKcl.13, PRKWNK2, RGD1307284, SDCCAG43, WNK lysine deficient protein kinase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wnk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- Oxidative-stress-responsive kinase 1 C-terminal domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- coronary artery disease
- hereditary disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
- androgenic alopecia
- essential tremor
role in cell
- growth
- proliferation
- phosphorylation in
- activation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wnk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of canonical Wnt receptor signaling pathway
- protein autophosphorylation
- ion homeostasis
- protein phosphorylation
- intracellular signal transduction
- positive regulation of sodium ion transmembrane transporter activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity