WNK2 Gene Summary [Human]
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Details
| Type | Protein Coding |
| Official Symbol | WNK2 |
| Official Name | WNK lysine deficient protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:14542] |
| Ensembl ID | ENSG00000165238 |
| Bio databases IDs | |
| Aliases | WNK lysine deficient protein kinase 2 |
| Synonyms | 1810073P09RIK, ESTM15, LOC105376151, mKIAA1760, NY-CO-43, P/OKcl.13, PRKWNK2, RGD1307284, SDCCAG43, WNK lysine deficient protein kinase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WNK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- Oxidative-stress-responsive kinase 1 C-terminal domain
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar disorder
- coronary artery disease
- hereditary disorder
- lung adenocarcinoma
- lung adenocarcinoma formation
- androgenic alopecia
- essential tremor
role in cell
- growth
- proliferation
- phosphorylation in
- activation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human WNK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- negative regulation of ERK1 and ERK2 cascade
- positive regulation of canonical Wnt receptor signaling pathway
- protein autophosphorylation
- ion homeostasis
- protein phosphorylation
- intracellular signal transduction
- positive regulation of sodium ion transmembrane transporter activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity